Meaning
To destroy, ruin, wreck, or break something badly — and, as a noun or adjective, something in a state of ruin. It implies far more thorough damage than plain 'break': a 'mash-up' car is a wreck, a 'mash-up' relationship is in pieces, and to 'mash up di place' is to smash it (or, in praise, to tear up the show). Suggesting a thing broken beyond easy repair, it is among the most versatile words for destruction, running from a literal wreck to a plan, a party, or a life falling apart.
Examples
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Di storm mash up di whole a mi roof.
The storm destroyed my entire roof.
Thorough destruction rather than a single break.
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Yuh mash up di plan when yuh chat too much.
You ruined the plan when you talked too much.
Figurative sense of spoiling something.
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Mi car mash up an mi cyaan drive it.
My car is wrecked and I can't drive it.
Adjectival use describing a broken-down state.
Origin
From English 'mash' (to crush) plus 'up', a common Patois intensifying particle that stresses completeness of the action.
How it’s used
Very common and appropriate in all casual settings. Can also positively describe a great performance ('di artiste mash up di show' means he thrilled the crowd), so context decides whether it is praise or damage. Widely known abroad through reggae and dancehall.