Meaning
To fixate on and persistently harass, pester, or victimise someone — to 'take set on' a person is to single them out and keep after them relentlessly, whether with teasing, blame, spiritual harm, or plain bother. It suggests a settled, ongoing campaign against one target rather than a one-off.
Examples
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Di bwoy dem tek set pon di likkle one a school.
The boys keep picking on the little one at school.
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Bad luck tek set pon mi dis year.
Bad luck has fixed itself on me this year.
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Why yuh tek set pon mi so?
Why do you keep harassing me like this?
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Di bigger bwoy dem tek set pon di likkle one.
The bigger boys kept picking on the little one.
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Since mi seh no, she tek set pon mi.
Since I said no, she's been on my case constantly.
Origin
From 'take' + 'set' (settle/fix upon) + 'pon' (upon); the image is of trouble settling onto one target. See Pon, Facety.
How it’s used
To persistently harass or victimise one person; also of misfortune 'settling' on someone. See Facety, Badmind.