Meaning
To spend — the Patois pronunciation of 'spend', with the final 'd' dropped. 'Him spen off all him money' means he spent it all, blew the lot. A free-spending man who flashes his cash is celebrated (or mocked) in dancehall as a 'spenda', and the whole talk of spending, saving, and being broke turns on the word. Among the everyday verbs of money and survival, 'spen' names the constant outgoing of cash in a place where money is tight and how a person spends says much about them.
Examples
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Him spen off him whole pay inna one night.
He spent his whole pay in one night.
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Nuh spen weh yuh nuh have.
Don't spend what you don't have.
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She love spen pon clothes.
She loves to spend on clothes.
Origin
The Patois pronunciation of 'spend', with the final consonant dropped (a common Patois feature).
How it’s used
Means 'spend'; a big spender is a 'spenda'. Compare 'floss', 'moneyman', 'bruk-pocket'.