Meaning
To leave alone, let be, or let go of. 'Lowe mi!' means 'leave me alone, stop bothering me', and to 'lowe di argument' is to drop it and let it rest. It is a plea or a command to cease meddling, release your hold, and let a person or a matter be, and it carries the plain force of wanting to be left in peace. Of African-derived origin, it is among the everyday words for backing off and letting things go.
Examples
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Lowe mi, mi nuh inna it today.
Leave me alone, I'm not in the mood today.
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Lowe di pickney, mek him play.
Leave the child alone, let him play.
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Just lowe it, it nuh worth it.
Just let it go, it isn't worth it.
Origin
From English 'allow' — to allow something to be, hence to leave it alone; worn down in Jamaican to 'lowe'.
How it’s used
A very common command to back off or drop a matter. 'Lowe mi' can be a firm, even sharp, request to be left in peace.