Meaning
A fool or a dupe — 'a proper Charlie' is someone made to look ridiculous or taken for a ride, and to 'mek a Charlie' out of a person is to make a fool of them. The word casts the mocked one as a figure of ridicule, hoodwinked or shown up before all. (Note that Charlie is also simply a common name and a casual, friendly term of address for a man, so context tells the fool from the friend.) In its insulting sense it belongs to the vocabulary of ridicule and the loss of face.
Examples
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Dem mek a Charlie out a him.
They made a fool out of him.
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Nuh stand up deh like a proper Charlie.
Don't stand there like a right fool.
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Wah gwaan, Charlie?
What's up, man?
Origin
From British slang 'a proper Charlie' (a fool); also a common given name used casually to address a man.
How it’s used
A fool/dupe ('proper Charlie'); also a friendly address for a man. Compare 'mumu', 'eediat'.